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Model
Model ID
recon_2_02 
Name
Human metabolism global reconstruction (Recon 2) - version 2.02 
Model Version
1.25 
Parent Model
 
Public
Organism
Homo sapiens 
SBML File
Image Map
 
Additional Files
 
Taxonomy
9606 
Genome Sequence
 
Biomass Composition
 
Parameter Estimation
 
Regulatory Constraints
 
Growth Conditions
 
License
CC 
Creator Stephan Pabinger
Institute Section for Bioinformatics
Comment
Thiele2013 - Human metabolism global reconstruction (Recon 2)

Community-driven global reconstruction of human metabolism.

This model is described in the article:

Thiele I, et al.
Nature Biotechnology

Abstract:

Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven, consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

 
Accepted
Change Comment
 
Date
Nov 21, 2013 6:39:12 PM 
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